AstraZeneca
As a Senior Director, Global Clinical Program Lead, you’ll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients’ lives. The successful Study and Program Clinical Lead in Late Phase CVRM (Cardiovascular, Renal, and Metabolic diseases) will be responsible for the design, conduct, monitoring, data interpretation and reporting of clinical trials ensuring that the clinical data collected within the study will allow determination of the benefits and risks of the compound, as well as will allow for the intended label indication and price in markets globally. The individual will operate according to the highest ethical standards in compliance with internal SOPs, local regulations, laws, Good Clinical Practice, and regulatory requirements.
Responsibilities
Provides strategic medical and scientific knowledge (Cardiovascular, Renal, Metabolic, and/or Liver Disease) and supports the design, initiation, execution, completion, and interpretation of a clinical study
Is accountable for study designs
Is accountable to deliver medical information, answers, and clarifications to Regulators, Ethic Committees, Marketing Companies, Investigators/Sites
Often works as a Global Clinical Head (GCH) delegate across several studies (e.g. a paediatric programme, or a set of mechanistic / differentiating studies)
Can be the clinical representative on indication Global Product Teams and/or other sub-teams
Has the knowledge to work across projects, with a fast learning curve when moving into new disease area
Is accountable to the Global Clinical Head (GCH) or delegate for the medical aspects and designs of studies
Is responsible for driving decisions within Study Team (ST) remits together with other ST members and for solving medical issues in the study team
Is accountable for the medical and ethical components of studies including patient safety on a study level in compliance with GCP
Is accountable for delivery of the clinical components of all relevant study documents (e.g Protocol, Amendments, Statistical Analysis Plan, Informed Consent Form, Case Report Forms, and Safety and Risk-Based Monitoring Plans)
Is accountable for ensuring that safety surveillance on a study level including the process for Adverse Events (AE)/ Serious AE reporting, the querying of missing/unclear data, the review of blinded safety data, and the escalation to the GCH/Global Safety Physician when needed.
Is medically accountable for international investigator meetings, and supports Marketing Companies (MC) in national activities
Approves (with the GCH) the Clinical Study Report; including preparation and production thereof (Introduction, Results, Discussion).
Is accountable for ST induction and education of new members in the study team, as well as others involved in the study
Collaborates seamlessly and efficiently with global colleagues at other R&D sites
May be accountable to GCH (or delegate) and leadership for identifying risks and proposing mitigation strategies to deliver successful Phase II, III, IV or Life Cycle Management studies
Stays updated on relevant scientific literature
Delivers analyses of clinical data in a balanced, statistically sound fashion, to drive interpretations and further idea generation
Serves as a source of medical expertise for the Product Team, in analyses and interpretation of medical data
Maintains a high degree of understanding and awareness on new and emerging medical development, globally.
Works with international colleagues and with external Alliance partners on development initiatives and regulatory issues
Applies strategic intent of AstraZeneca when working with Alliance partners, Regulatory Authorities, payers, opinion leaders, prescribers and consumers of AstraZeneca products
Able to provide guidance for investigator-initiated trials in cooperation with regional marketing companies
Accountable for building trustworthy relationships with steering committees/executive committees with AROs/CROs
Maintains strong networks globally with KEEs, prescribers, regulators and payers
Requeriments
Graduate of a recognized school of medicine with an M.B.B.S., M.D. degree or equivalent, and/or a graduate of a scientific doctorate (e.g. PhD or PharmD) or equivalent in a scientific discipline or Pharmaceutical Medicine
3+ years clinical research expertise in relevant therapy area in study design, protocol development, monitoring and implementing clinical trials, interpreting and reporting trial results
Good knowledge of biostatistics, global regulatory environment and pharmacovigilance
Proven teamwork and collaboration skills
Fluent in oral and written English
Good presentation skills and effective communication
Leadership qualities, with particular focus on collaborative working skills, trust and openness, irrespective of cultural setting
AstraZeneca values and behaviors
Agile responsiveness to scientific data
Credibility in scientific and commercial environments
Desired Experience
Good general medical knowledge preferably in nephrology, cardiology, metabolic, or NASH
Preferably 3-5 years in the pharmaceutical industry, with an understanding of R&D, particularly of major clinical milestones and of the factors which influence drug development
An understanding of the interplay between clinical, commercial objectives, drug safety and regulatory requirements
Education in Pharmaceutical Medicine
Experience from different organizations
AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics.
We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.
The annual base pay for this position ranges from 288,059.20 - 432,088.80 SD Annual . Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.
Date Posted
01-Jul-2026
Closing Date
08-Jul-2026
Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.