Senior Clinical Research Associate - Oncology

We currently have a vacancy for a Clinical Research Associate in our Oncology team. This is initially a 12 Month Max Term contract position.

At AstraZeneca, we’re united by a bold ambition: to transform patients’ lives through science. Across BioPharma and Oncology, we design and deliver high‑quality, patient‑centric clinical trials that translate deep biology into breakthrough medicines in cardiovascular, renal & metabolism, respiratory & immunology, and cancers where the need is greatest.

As a Clinical Research Associate, you will own site activation and performance, direct risk-based monitoring to where it matters most, and safeguard patient safety and data integrity. You will partner with investigators, shape inspection readiness, and apply a forward-looking approach that challenges the status quo and accelerates launches. How will you use your judgment and influence to turn a promising protocol into a reliable, scalable trial outcome.

What you’ll do 

• Identify and evaluate sites and investigators, build collaborative relationships, and drive activation, enrolment and sustained performance.
• Coordinate EC/IRB and health‑authority submissions, secure and maintain approvals, and manage essential documents to keep studies inspection‑ready from day one.
• Train and support site teams on ICH‑GCP and RbQM, embed compliance routines, and coach toward audit and inspection readiness.
• Conduct remote and onsite monitoring visits; perform Source Data Review (SDR), Source Data Verification (SDV) and Case Report Form (CRF) review; manage data queries; and adjust monitoring intensity based on risk signals.
• Ensure timely reporting of Serious Adverse Events (SAEs); proactively identify, escalate and resolve quality issues in line with AstraZeneca SOPs.
• Maintain CTMS and eTMF accuracy; manage study drug supplies and accountability; and deliver clear, timely monitoring reports and follow‑up.

Essential for the role 

• Bachelor’s degree in a life science or related field (or equivalent experience).
• Solid understanding of the drug development process, ICH‑GCP and relevant country regulations.
• Experience in site selection, activation and monitoring (remote and onsite) with strong documentation discipline.
• Proficiency with CTMS/eTMF and data‑query management; familiarity with SDR/SDV/CRF review.
• Strong communication, stakeholder management and problem‑solving skills; ability to work independently and as part of a cross‑functional team.